Panthers vs. Titans prediction, odds, spread, injuries, trends for NFL Week 12

A full betting preview for the Tennessee Titans' Week 12 matchup against the Carolina Panthers.
Tennessee Titans running back Derrick Henry (22) runs the ball before an NFL football matchup
Tennessee Titans running back Derrick Henry (22) runs the ball before an NFL football matchup / Corey Perrine/Florida Times-Unio / USA

Bryce Young and the Carolina Panthers haven’t played great this season, losing four out of their last five games. At the same time, the Titans are struggling too, but they may have found something at the QB spot with Will Levis.

No one had this rookie quarterback matchup circled on their calendar before the season began, but we will see how it plays on Sunday afternoon. The Titans are favored by more than a field goal over the Panthers in this matchup. Can Tennessee cover this number, or will Young get the better of his rookie classmate?

Below, we will break down this game and provide our best bet for this late-season rookie QB matchup between the Panthers and Titans.

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Panthers vs. Titans Odds, Spread and Total

Panthers vs. Titans Betting Trends

  • The UNDER is 4-1 in Carolina’s last five games
  • The Panthers are 1-4 ATS on the road this season
  • Tennessee is 3-1 ATS at home this season
  • The Titans are 1-4 straight up in their past five games vs. an NFC team

Panthers vs. Titans Injury Reports

Panthers Injury Report

  • Dicaprio Bootle - CB - IR
  • Austin Corbett - OG - IR
  • Hayden Hurst - TE - Questionable
  • Marquis Haynes Sr. - LB - Questionable
  • CJ. Henderson - CB - Questionable

Titans Injury Report

  • Treylon Burks - WR - Questionable
  • Sean Murphy-Bunting - CB - Questionable
  • Andre Dillard - OT - Questionable
  • Terrell Edmunds - S - Questionable
  • K’Von Wallace - S - Questionable

Panthers vs. Titans How to Watch

  • Date: Sunday, Nov. 26
  • Game Time: 1:00 p.m. EST
  • Venue: Nissan Stadium
  • How to Watch (TV): FOX
  • Panthers Record: 1-9
  • Titans Record: 3-7

Panthers vs. Titans Key Players to Watch

Carolina Panthers

Bryce Young: Young had a rough outing last week against the Cowboys. The rookie QB completed 55.2% of his passes for a touchdown and an interception. Young was also sacked a season-high seven times. It hasn’t been an easy transition for the former Alabama star quarterback, who was one of the more accurate QBs in last year’s class. He will try to rebound against the Titans’ defense on Saturday, which allows opposing QBs to complete 68.8% of their passes.

Tennessee Titans

Derrick Henry: Henry hasn’t looked like the explosive running backs we’ve seen over the past few years this season. The veteran running back has rushed for 663 yards and four touchdowns in 10 games. Henry was held to 2.9 yards per carry in his last two games, which shows his struggles behind a less-than-stellar offensive line. However, the good news for Henry is that he’s playing a Carolina defense that allows 129.4 rushing yards per game and 4.3 rushing yards per attempt.

Panthers vs. Titans Prediction and Pick

Carolina hasn’t had the best of luck on the road this season (0-5), as they’re getting outscored by 13.2 points per game. The last time we saw the Panthers on the road, they lost by three points to the Bears.

There’s a possibility that Sunday’s game against Tennessee is low-scoring, which benefits the Panthers, who only score 16.3 points per game this season. However, the key for Carolina will be whether they can protect Young and find some consistency in the running game.

The Panthers’ offensive line should be able to hold up against the Titans’ defense, which only has 26 sacks this season. However, I don’t see Miles Sanders or Chuba Hubbard running wild on Tennessee's defense. The Titans allow 112.3 rushing yards per game and 3.9 yards per carry.

As for the Titans’ offense, the game plan is simple; Levis just needs to manage the game and hope for a Derrick Henry breakout game. Tennessee is 3-1 at home this season, which includes wins over Atlanta and Cincinnati. It won’t be a pretty game, but I like what Tennessee has on both sides to get the win.

Game odds refresh periodically and are subject to change.