Tennessee Titans vs. Buffalo Bills: Best matchups

NASHVILLE, TENNESSEE - OCTOBER 06: Derrick Henry #22 of the Tennessee Titans poses in the end zone after scoring a touchdown against the Buffalo Bills during the second half at Nissan Stadium on October 06, 2019 in Nashville, Tennessee. (Photo by Frederick Breedon/Getty Images)
NASHVILLE, TENNESSEE - OCTOBER 06: Derrick Henry #22 of the Tennessee Titans poses in the end zone after scoring a touchdown against the Buffalo Bills during the second half at Nissan Stadium on October 06, 2019 in Nashville, Tennessee. (Photo by Frederick Breedon/Getty Images) /
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(Photo by Brett Carlsen/Getty Images)
(Photo by Brett Carlsen/Getty Images) /

Tennessee Titans running game vs. Buffalo Bills front seven

It’ll be no surprise if the Titans give Derrick Henry 30-plus carries in this game.

The Titans are going to – more than likely – be without Corey Davis, Adam Humphries, Cameron Batson, and MyCole Pruitt. With A.J. Brown returning from a bone bruise injury and Kalif Raymond and Nick Westbrook-Ikhine being forced into the biggest roles of their young careers, the Titans’ running game will have to operate at full efficiency if the Titans want to squeak out a victory.

The Titans finally seemed to be hitting their stride in terms of running the football the last time we saw them play. Against the Minnesota Vikings in Week 3, Henry carried the ball 26 times for 119 yards and two touchdowns. Henry looked much quicker and decisive than he had the first two weeks, and the offensive line was creating much more daylight.

The Buffalo Bills front seven isn’t quite what it used to be in recent years. Run-stuffer Kyle Williams has retired and Ed Oliver hasn’t been the dominant lineman they drafted him to be. Mario Addison and Jerry Hughes are very solid EDGEs, but they aren’t great in run defense. Then we get to the linebacker position, where the Bills are really hurting. Matt Milano, one of the best run-defending thumpers in the NFL, is going to miss his second game of the season. Tremaine Edmunds has been nagged by injury this season and grades out as one of the worst ILBs in the league, according to PFF.

Darrell Henderson and the Rams ran wild on this Bills defense in Week 3, and Henry should do the same if given the opportunity.