Mike Moraitis:
The Titans and Bills have two of the best defenses in the NFL through four weeks, and I expect that to continue in Week 5. As such, this will be a slug-it-out defensive game that will be low-scoring and will come down to who makes the big defensive play in the fourth quarter.
The biggest difference between these two teams comes in the turnover department. No quarterback in the NFL has taken care of the ball better than Marcus Mariota, while on the flip side the Bills are near the top of the league in both interceptions and turnovers in general.
The Titans will stop the Bills on the ground, forcing Josh Allen to beat them with his arm. That will lead to mistakes, and Allen will make the big mistake late that ends up deciding this game. The Titans will move to 3-2 on the season after a home win against the Bills.
Titans 20, Bills 13